THE ROLE OF MICRORNA IN PREDICTING DEMENTIA IN HIV PATIENTS

Authors

  • S. K. Utegenova
  • A. K. Bayjanov

Abstract

In recent years, based on molecular biological research methods, new forms of
ribonucleic acid (RNA) have been discovered - a non-coding RNA family, the socalled "microRNA" or "miRNA". MicroRNAs are RNAs composed of 18-25
nucleotides. Recently, it was found that microRNAs play a vital role in the
mechanisms underlying the development and functioning of the central nervous
system. To date, more than 2,200 microRNAs have been found in the human body,
which is involved in the regulation of about 30% of the human genome. It has been
shown that microRNAs are present in the so-called circulating form. Dysregulation of
miRNA, characterized by an increase or decrease in expression, suggests that
circulating miRNAs may be of interest as non-invasive biomarkers.
The aim of this research: To assess the role of microRNA29a, microRNA134,
and microRNA3665 as biomarkers of the development of HIV dementia and factors
that may contribute to the development of this pathology in patients with HIV
infection.
Material and methods of research:

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Published

2021-09-12